Skip to main content

[/what-is-hantavirus]

What is hantavirus?

Hantaviruses are a family of viruses spread mainly by rodents that can cause severe illness in humans.

[01] Overview

A virus family with two clinical faces

Genus
Orthohantavirus
Family
Hantaviridae
Genome
Negative-sense ssRNA
Main hosts
Rodents (also shrews, moles, bats)
Two syndromes
HPS · HFRS
Person-to-person
Andes virus only

[02] Transmission

How hantavirus reaches humans

Most infections happen by inhaling aerosols of dried rodent excreta in enclosed spaces. Direct contact with rodents, bites, or contaminated food are rarer. The Andes virus is the only strain with documented person-to-person transmission, and even then close prolonged contact is required.

Hantavirus transmission pathway

RODENThost reservoirEXCRETAurine · droppings · salivaAEROSOLdried particles airborneHUMANinhalation → infection
// Source: CDC, WHO. Person-to-person transmission only documented for the Andes virus.

[03] Symptoms

Clinical timeline

Symptoms typically begin 1 to 8 weeks after exposure with flu-like signs, then progress rapidly. Early hospitalisation significantly improves outcomes.

Hantavirus pulmonary syndrome — clinical timeline

  1. Day 0
    Exposure

    Inhalation of contaminated aerosol

  2. Day 1 – 56
    Incubation

    Asymptomatic. 1 to 8 weeks.

  3. Day 1 – 5 (prodrome)
    Flu-like phase

    Fever · myalgia · fatigue · headache · GI symptoms

  4. Day 4 – 10
    Cardiopulmonary

    Cough · dyspnea · ARDS · hypotension

  5. Day 10+
    Diuresis & recovery

    Or fatal outcome (CFR ~25–40 % for Andes / Sin Nombre)

[04] HPS / HFRS

Two syndromes, two organs

▣ HPS vs HFRS — clinical comparison

HPSCFR · 25 – 40 %

Hantavirus pulmonary syndrome

Region
Americas
Strains
Sin Nombre · Andes
Mechanism
Capillary leak in the lungs · acute respiratory distress
HFRSCFR · < 1 % to 12 %

Haemorrhagic fever with renal syndrome

Region
Europe · Asia
Strains
Hantaan · Seoul · Puumala · Dobrava
Mechanism
Acute kidney injury · haemorrhage · proteinuria

[05] Strains

Major strains and their reservoirs

Andes virus

HPS

Andes orthohantavirus (ANDV)

Reservoir
Long-tailed pygmy rice rat (Oligoryzomys longicaudatus)
Region
Argentina, Chile (southern South America)
CFR
~25–40%

Only hantavirus with documented person-to-person transmission. Suspected strain in MV Hondius outbreak.

CDC — Hantavirus reservoirs

Sin Nombre virus

HPS

Sin Nombre orthohantavirus (SNV)

Reservoir
Deer mouse (Peromyscus maniculatus)
Region
United States, Canada, Mexico
CFR
~36% (US)

Most common cause of hantavirus pulmonary syndrome (HPS) in North America. Identified during the 1993 Four Corners outbreak.

CDC — Hantavirus pulmonary syndrome

Puumala virus

HFRS

Puumala orthohantavirus (PUUV)

Reservoir
Bank vole (Myodes glareolus)
Region
Northern and central Europe (Finland, Germany, France, Sweden)
CFR
<0.5%

Causes a milder form of HFRS known as nephropathia epidemica. Most common hantavirus in Europe.

ECDC — Puumala virus factsheet

Seoul virus

HFRS

Seoul orthohantavirus (SEOV)

Reservoir
Brown rat (Rattus norvegicus)
Region
Worldwide (urban)
CFR
~1–2%

Spread globally via the brown rat. Documented outbreaks linked to pet-rat breeders.

CDC — Seoul virus

Hantaan virus

HFRS

Hantaan orthohantavirus (HTNV)

Reservoir
Striped field mouse (Apodemus agrarius)
Region
East Asia (Korea, China, Russian Far East)
CFR
~5–15%

Severe form of HFRS. Originally identified after the Korean War; gave the family its name.

WHO — Hantavirus disease

Dobrava-Belgrade virus

HFRS

Dobrava-Belgrade orthohantavirus (DOBV)

Reservoir
Yellow-necked field mouse (Apodemus flavicollis)
Region
Balkans, Eastern Europe
CFR
~10–12%

Causes severe HFRS in the Balkans.

ECDC — Hantavirus surveillance

[06] Mortality

Case fatality at a glance

▣ Case fatality rate by strain

Andes virus
25–40%
Sin Nombre virus
30–40%
Puumala virus
0–0.5%
Seoul virus
1–2%
Hantaan virus
5–15%
Dobrava-Belgrade virus
10–12%
Scale
0%10%20%30%40%
// Sources: CDC, WHO, ECDC. Ranges aggregate published values; actual outcomes depend on care availability.

[07] Prevention

Reduce rodent contact

There is no licensed antiviral therapy for hantavirus disease in Europe or North America. Care is supportive. Prevention focuses on reducing rodent exposure and handling rodent-infested spaces safely.

▣ Six prevention measures

  • Seal entry points

    Close gaps > 6 mm in walls, doors, roofs, around utility lines.

  • Rodent-proof storage

    Store food, pet food and rubbish in sealed containers.

  • Trap, do not poison

    Snap traps reduce dispersal. Wear gloves to handle them.

  • Ventilate before cleaning

    Open the space for at least 30 minutes before entering.

  • Wet, do not sweep

    Spray droppings with a 1:10 bleach solution. Never sweep dry.

  • Wear N95 / FFP2 + gloves

    Use respirator, nitrile gloves and eye protection while cleaning.

// Source: CDC cleanup and prevention guidelines.

[08] History

Notable milestones

  1. 1976

    Hantaan virus identified

    Isolated from striped field mice near the Hantan River, Korea — gives the family its name.

  2. 1993

    Four Corners outbreak

    Discovery of Sin Nombre virus and characterisation of HPS in the southwestern USA.

  3. 2012

    Yosemite cluster

    Ten HPS cases linked to rodent infestation in tent cabins, prompting global alerts.

  4. 2026

    MV Hondius

    First documented hantavirus outbreak aboard a cruise ship — South Atlantic, April–May.

[09] FAQ

Frequently asked questions

Is hantavirus contagious between people?+

In almost all cases, no. Most hantaviruses spread from rodents to humans via inhaled aerosols of infected urine, droppings, or saliva. The Andes virus, found in southern South America, is the only strain with documented person-to-person transmission. (Source: CDC, WHO.)

What are the early symptoms of hantavirus?+

Early symptoms typically appear 1–8 weeks after exposure and resemble flu: fever, severe muscle aches, fatigue, headache, dizziness, chills, nausea, vomiting and abdominal pain. Within 4–10 days the disease can progress rapidly to severe respiratory distress (HPS) or kidney failure (HFRS). (Source: CDC.)

How is hantavirus diagnosed?+

Diagnosis relies on serological testing (IgM and IgG ELISA) or PCR. Because early symptoms mimic flu or COVID-19, doctors look for known exposure to rodents or recent travel to endemic regions. (Source: CDC, ECDC.)

Is there a treatment for hantavirus?+

There is no specific antiviral treatment approved for hantavirus disease. Care is supportive: oxygen therapy, fluid management, and intensive care including mechanical ventilation or dialysis where needed. Early hospitalisation improves outcomes. (Source: CDC.)

What is the mortality rate of hantavirus?+

It depends on the strain. Hantavirus pulmonary syndrome (HPS) caused by Sin Nombre virus has a case fatality rate of around 36% in the US. Andes virus is similarly severe (~25–40%). HFRS caused by Puumala virus is much milder (<0.5% mortality). (Source: CDC, ECDC.)

How can I prevent hantavirus infection?+

Reduce rodent contact: seal entry points in homes and outbuildings, store food in rodent-proof containers, and use traps. Before cleaning rodent-infested areas, ventilate for 30 minutes, wet droppings with disinfectant rather than sweeping, wear gloves and an N95/FFP2 mask, and double-bag waste. (Source: CDC cleanup guidelines.)

What happened on the MV Hondius?+

The MV Hondius, a Dutch-flagged expedition vessel, departed Ushuaia (Argentina) on 1 April 2026 with 147 people on board. Three deaths and eight cases (three lab-confirmed) of suspected hantavirus were reported between late April and early May 2026. The Andes strain has been confirmed in at least one disembarked passenger. WHO assesses the risk to the general public as low. (Source: WHO, Oceanwide Expeditions, CNN, Al Jazeera.)

Can hantavirus spread on a cruise ship?+

Hantaviruses are not airborne in the way respiratory viruses such as influenza or SARS-CoV-2 are. The Andes strain is the only one with documented person-to-person transmission, and even then, transmission requires close prolonged contact. WHO has stated the public risk from the MV Hondius outbreak is low. (Source: WHO statements, May 2026.)

Is there a hantavirus vaccine?+

No vaccine is currently licensed in Europe or North America. Inactivated-virus vaccines for Hantaan and Seoul viruses are licensed in South Korea and China. Several candidate vaccines for Andes and Sin Nombre viruses are in clinical or preclinical development. (Source: WHO.)

Where is hantavirus found in the world?+

Hantaviruses are found on every inhabited continent. Major distribution: Sin Nombre virus (Americas, North), Andes virus (Argentina/Chile), Puumala virus (Northern Europe), Hantaan and Seoul viruses (Asia and worldwide via brown rats), Dobrava-Belgrade (Balkans). (Source: WHO, CDC, ECDC.)

What is the difference between HPS and HFRS?+

Hantavirus pulmonary syndrome (HPS) primarily attacks the lungs and is caused by New World hantaviruses (Americas). Haemorrhagic fever with renal syndrome (HFRS) primarily affects the kidneys and is caused by Old World hantaviruses (Europe, Asia). HPS is generally more lethal. (Source: CDC.)

Should I cancel travel because of hantavirus?+

For most travellers, no. WHO and major travel-health authorities currently advise standard precautions, not cancellation. Avoid contact with wild rodents, do not enter rodent-infested cabins or sheds without ventilation and PPE, and follow local health advice. (Source: WHO, CDC traveller health.)

Get outbreak alerts

Get outbreak alerts

We email you when WHO updates the case count or a new country is affected. No spam.

// I agree to receive outbreak update emails. I can unsubscribe at any time.

// Sources: WHO · CDC · ECDC. Educational content; not a substitute for professional medical advice.

What is hantavirus? · Hantavirus Live