[/what-is-hantavirus]
What is hantavirus?
Hantaviruses are a family of viruses spread mainly by rodents that can cause severe illness in humans.
[01] Overview
A virus family with two clinical faces
[02] Transmission
How hantavirus reaches humans
Most infections happen by inhaling aerosols of dried rodent excreta in enclosed spaces. Direct contact with rodents, bites, or contaminated food are rarer. The Andes virus is the only strain with documented person-to-person transmission, and even then close prolonged contact is required.
▣ Hantavirus transmission pathway
[03] Symptoms
Clinical timeline
Symptoms typically begin 1 to 8 weeks after exposure with flu-like signs, then progress rapidly. Early hospitalisation significantly improves outcomes.
▣ Hantavirus pulmonary syndrome — clinical timeline
Inhalation of contaminated aerosol
Asymptomatic. 1 to 8 weeks.
Fever · myalgia · fatigue · headache · GI symptoms
Cough · dyspnea · ARDS · hypotension
Or fatal outcome (CFR ~25–40 % for Andes / Sin Nombre)
- Day 0Exposure
Inhalation of contaminated aerosol
- Day 1 – 56Incubation
Asymptomatic. 1 to 8 weeks.
- Day 1 – 5 (prodrome)Flu-like phase
Fever · myalgia · fatigue · headache · GI symptoms
- Day 4 – 10Cardiopulmonary
Cough · dyspnea · ARDS · hypotension
- Day 10+Diuresis & recovery
Or fatal outcome (CFR ~25–40 % for Andes / Sin Nombre)
[04] HPS / HFRS
Two syndromes, two organs
▣ HPS vs HFRS — clinical comparison
Hantavirus pulmonary syndrome
- Region
- Americas
- Strains
- Sin Nombre · Andes
- Mechanism
- Capillary leak in the lungs · acute respiratory distress
Haemorrhagic fever with renal syndrome
- Region
- Europe · Asia
- Strains
- Hantaan · Seoul · Puumala · Dobrava
- Mechanism
- Acute kidney injury · haemorrhage · proteinuria
[05] Strains
Major strains and their reservoirs
Andes virus
HPSAndes orthohantavirus (ANDV)
- Reservoir
- Long-tailed pygmy rice rat (Oligoryzomys longicaudatus)
- Region
- Argentina, Chile (southern South America)
- CFR
- ~25–40%
Only hantavirus with documented person-to-person transmission. Suspected strain in MV Hondius outbreak.
CDC — Hantavirus reservoirsSin Nombre virus
HPSSin Nombre orthohantavirus (SNV)
- Reservoir
- Deer mouse (Peromyscus maniculatus)
- Region
- United States, Canada, Mexico
- CFR
- ~36% (US)
Most common cause of hantavirus pulmonary syndrome (HPS) in North America. Identified during the 1993 Four Corners outbreak.
CDC — Hantavirus pulmonary syndromePuumala virus
HFRSPuumala orthohantavirus (PUUV)
- Reservoir
- Bank vole (Myodes glareolus)
- Region
- Northern and central Europe (Finland, Germany, France, Sweden)
- CFR
- <0.5%
Causes a milder form of HFRS known as nephropathia epidemica. Most common hantavirus in Europe.
ECDC — Puumala virus factsheetSeoul virus
HFRSSeoul orthohantavirus (SEOV)
- Reservoir
- Brown rat (Rattus norvegicus)
- Region
- Worldwide (urban)
- CFR
- ~1–2%
Spread globally via the brown rat. Documented outbreaks linked to pet-rat breeders.
CDC — Seoul virusHantaan virus
HFRSHantaan orthohantavirus (HTNV)
- Reservoir
- Striped field mouse (Apodemus agrarius)
- Region
- East Asia (Korea, China, Russian Far East)
- CFR
- ~5–15%
Severe form of HFRS. Originally identified after the Korean War; gave the family its name.
WHO — Hantavirus diseaseDobrava-Belgrade virus
HFRSDobrava-Belgrade orthohantavirus (DOBV)
- Reservoir
- Yellow-necked field mouse (Apodemus flavicollis)
- Region
- Balkans, Eastern Europe
- CFR
- ~10–12%
Causes severe HFRS in the Balkans.
ECDC — Hantavirus surveillance[06] Mortality
Case fatality at a glance
▣ Case fatality rate by strain
[07] Prevention
Reduce rodent contact
There is no licensed antiviral therapy for hantavirus disease in Europe or North America. Care is supportive. Prevention focuses on reducing rodent exposure and handling rodent-infested spaces safely.
▣ Six prevention measures
Seal entry points
Close gaps > 6 mm in walls, doors, roofs, around utility lines.
Rodent-proof storage
Store food, pet food and rubbish in sealed containers.
Trap, do not poison
Snap traps reduce dispersal. Wear gloves to handle them.
Ventilate before cleaning
Open the space for at least 30 minutes before entering.
Wet, do not sweep
Spray droppings with a 1:10 bleach solution. Never sweep dry.
Wear N95 / FFP2 + gloves
Use respirator, nitrile gloves and eye protection while cleaning.
[08] History
Notable milestones
- 1976
Hantaan virus identified
Isolated from striped field mice near the Hantan River, Korea — gives the family its name.
- 1993
Four Corners outbreak
Discovery of Sin Nombre virus and characterisation of HPS in the southwestern USA.
- 2012
Yosemite cluster
Ten HPS cases linked to rodent infestation in tent cabins, prompting global alerts.
- 2026
MV Hondius
First documented hantavirus outbreak aboard a cruise ship — South Atlantic, April–May.
[09] FAQ
Frequently asked questions
Is hantavirus contagious between people?+
In almost all cases, no. Most hantaviruses spread from rodents to humans via inhaled aerosols of infected urine, droppings, or saliva. The Andes virus, found in southern South America, is the only strain with documented person-to-person transmission. (Source: CDC, WHO.)
What are the early symptoms of hantavirus?+
Early symptoms typically appear 1–8 weeks after exposure and resemble flu: fever, severe muscle aches, fatigue, headache, dizziness, chills, nausea, vomiting and abdominal pain. Within 4–10 days the disease can progress rapidly to severe respiratory distress (HPS) or kidney failure (HFRS). (Source: CDC.)
How is hantavirus diagnosed?+
Diagnosis relies on serological testing (IgM and IgG ELISA) or PCR. Because early symptoms mimic flu or COVID-19, doctors look for known exposure to rodents or recent travel to endemic regions. (Source: CDC, ECDC.)
Is there a treatment for hantavirus?+
There is no specific antiviral treatment approved for hantavirus disease. Care is supportive: oxygen therapy, fluid management, and intensive care including mechanical ventilation or dialysis where needed. Early hospitalisation improves outcomes. (Source: CDC.)
What is the mortality rate of hantavirus?+
It depends on the strain. Hantavirus pulmonary syndrome (HPS) caused by Sin Nombre virus has a case fatality rate of around 36% in the US. Andes virus is similarly severe (~25–40%). HFRS caused by Puumala virus is much milder (<0.5% mortality). (Source: CDC, ECDC.)
How can I prevent hantavirus infection?+
Reduce rodent contact: seal entry points in homes and outbuildings, store food in rodent-proof containers, and use traps. Before cleaning rodent-infested areas, ventilate for 30 minutes, wet droppings with disinfectant rather than sweeping, wear gloves and an N95/FFP2 mask, and double-bag waste. (Source: CDC cleanup guidelines.)
What happened on the MV Hondius?+
The MV Hondius, a Dutch-flagged expedition vessel, departed Ushuaia (Argentina) on 1 April 2026 with 147 people on board. Three deaths and eight cases (three lab-confirmed) of suspected hantavirus were reported between late April and early May 2026. The Andes strain has been confirmed in at least one disembarked passenger. WHO assesses the risk to the general public as low. (Source: WHO, Oceanwide Expeditions, CNN, Al Jazeera.)
Can hantavirus spread on a cruise ship?+
Hantaviruses are not airborne in the way respiratory viruses such as influenza or SARS-CoV-2 are. The Andes strain is the only one with documented person-to-person transmission, and even then, transmission requires close prolonged contact. WHO has stated the public risk from the MV Hondius outbreak is low. (Source: WHO statements, May 2026.)
Is there a hantavirus vaccine?+
No vaccine is currently licensed in Europe or North America. Inactivated-virus vaccines for Hantaan and Seoul viruses are licensed in South Korea and China. Several candidate vaccines for Andes and Sin Nombre viruses are in clinical or preclinical development. (Source: WHO.)
Where is hantavirus found in the world?+
Hantaviruses are found on every inhabited continent. Major distribution: Sin Nombre virus (Americas, North), Andes virus (Argentina/Chile), Puumala virus (Northern Europe), Hantaan and Seoul viruses (Asia and worldwide via brown rats), Dobrava-Belgrade (Balkans). (Source: WHO, CDC, ECDC.)
What is the difference between HPS and HFRS?+
Hantavirus pulmonary syndrome (HPS) primarily attacks the lungs and is caused by New World hantaviruses (Americas). Haemorrhagic fever with renal syndrome (HFRS) primarily affects the kidneys and is caused by Old World hantaviruses (Europe, Asia). HPS is generally more lethal. (Source: CDC.)
Should I cancel travel because of hantavirus?+
For most travellers, no. WHO and major travel-health authorities currently advise standard precautions, not cancellation. Avoid contact with wild rodents, do not enter rodent-infested cabins or sheds without ventilation and PPE, and follow local health advice. (Source: WHO, CDC traveller health.)
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